This project aims to develop a gene therapy approach for Type 1 Diabetes Mellitus. It explains. It is difficult to treat due to its autoimmune features and development at a young age. autoantibody detection of this disease using Adeno-associated virus (AAV) vectors. It is aimed to be treated by replacing the genes that cause the response. This project, which was carried out by applying innovative methods, is open to development, but It promises patients the potential to be a great hope.